Product name:  Percocet


Active substance:  acetaminophen/oxycodone

Drug Class: Narcotic analgesic combinations

Pregnancy Category: C – Risk cannot be ruled out

CSA Schedule: 2 – High potential for abuse

Brand names: Percocet 10/325, Percocet 2.5/325, Percocet 5/325, Percocet 7.5/325, Primlev, Roxicet, Xartemis XR, Tylox, Roxilox, Endocet, Percocet 10/650, Percocet 7.5/500, Perloxx, Magnacet, Narvox, Primalev, Xolox, Endocet 2.5/325, Endocet 5/325, Endocet 7.5/325, Endocet 10/325, Nalocet

Dosage Strength(s): Percocet 2.5mg/325mg, Percocet 7.5mg/325mg, Percocet 5mg/325mg, Percocet 10mg/325mg

Quantity: 100 – 750 Tablets






Percocet is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesic combinations. Risk cannot be ruled out during pregnancy. Percocet is classified as a Schedule 2 controlled substance under the Controlled Substance Act (CSA).

Percocet can slow or stop your breathing, and may be habit-forming. Use only your prescribed dose, and swallow the pill whole to avoid a potentially fatal dose. Never share Percocet with another person.

MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

You should not use this medicine if you are allergic to acetaminophen (Tylenol) or oxycodone, or if you have: severe asthma or breathing problems; or a blockage in your stomach or intestines, including paralytic ileus.

To make sure this medicine is safe for you, tell your doctor if you have ever had: any type of breathing problem or lung disease; liver disease, cirrhosis, or if you drink alcohol daily; drug or alcohol addiction, or mental illness; kidney disease, urination problems; problems with your gallbladder, pancreas, thyroid, or adrenal gland; or a head injury, brain tumor, or seizures.

Some medicines can interact with oxycodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.



Usual Adult Dose for Pain


Oxycodone 2.5 mg/acetaminophen 300 or 325 mg: 1 to 2 tablets every 6 hours

Maximum dose: 12 tablets in 24 hours

Oxycodone 5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 12 tablets in 24 hours

Oxycodone 7.5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 8 tablets in 24 hours

Oxycodone 10 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 6 tablets in 24 hours

Oral Solution: Oxycodone 5 mg/acetaminophen 325 mg per 5 mL:

Usual dose: Oxycodone 5 mg/acetaminophen 325 mg (5 mL) orally every 6 hours as needed for pain

Maximum dose: Oxycodone 60 mg/acetaminophen 3900 mg (60 mL) in 24 hours

Verify dose in mg and mL prior to administration



As First Opioid Analgesic: 2 tablets orally every 12 hours (each ER tablet contains oxycodone 7.5 mg/acetaminophen 325 mg)

-The second dose may be administered as early as 8 hours after initial dose if needed; however, subsequent doses should be administered every 12 hours


-Doses should be individually titrated to provide adequate analgesia while minimizing adverse reactions.

-Because of the risks of addiction, abuse and misuse, the lowest effective dose for the shortest duration consistent with individual patient treatment goals should be used.

-Monitor patients closely for respiratory depression within the first 24 to 72 hours of initiating therapy and following any increase in dose.

Oxycodone/acetaminophen ER Tablets are not interchangeable with other oxycodone/acetaminophen products.

Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.


Renal Dose Adjustments


-Use with caution; therapy should be initiated with a lower than usual dose; titrate carefully

Extended-release (ER):

Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours; adjust does as needed

Liver Dose Adjustments


-Use with caution; therapy should be initiated with a lower than usual dose; titrate carefully

Extended-release (ER):

Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours; adjust dose as needed


Dose Adjustments

Elderly, Cachectic, or Debilitated Patients: Use with caution generally starting at the low end of the dosing range, titrate dose slowly while monitoring closely for signs of CNS or respiratory depression.

Maximum Acetaminophen Dose is 4 g in 24 hours

-Take into account all acetaminophen products when calculating daily dose.

-To avoid overdose of acetaminophen, it is best to use just 1 acetaminophen product at a time.

Concomitant Use of CNS depressants:

-Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours; adjust dose as needed

-Consider decreasing dose of concomitant CNS depressant drug; monitor for signs of respiratory depression, sedation, and hypotension.

-Concomitant use of CYP450 3A4 inducers or inhibitors may require dose adjustment: Consult drug interactions

Discontinuation of Therapy in the Physically Dependent Patient:

-Taper dose gradually, by 25% to 50% every 2 to 4 days

-Monitor for signs and symptoms of withdrawal; if they occur, raise the dose to the previous level and taper more slowly

-Do not abruptly discontinue in the physically dependent patient




Addiction, Abuse, and Misuse: This drug exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing and monitor all patients regularly for the development of these behaviors or conditions.

Life-Threatening Respiratory Depression: Serious, life-threatening, or fatal respiratory depression may occur, especially during initiation or following a dose increase.

-Accidental Ingestion: Accidental ingestion of even 1 dose, especially by children, can result in a fatal overdose of oxycodone.

Neonatal Opioid Withdrawal Syndrome: Prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, the patient should be advised of the risk of neonatal opioid withdrawal syndrome and ensure appropriate treatment will be available.

CYP450 3A4 Interaction: Concomitant use of CYP450 3A4 inhibitors may result in increased oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. In addition, discontinuation of a concomitantly used CYP450 3A4 inducer may result in increased oxycodone plasma concentrations. Monitor patients concomitantly receiving any CYP450 3A4 inhibitor or inducer.

Hepatotoxicity: Acetaminophen has been associated with case of acute liver failure, at times resulting in liver transplant and death; most cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 mg per day, and often involve more than one acetaminophen-containing product.

-Concomitant Use with Benzodiazepines or Other CNS Depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Concomitant use should be reserved for use in patients for whom alternative treatment options are inadequate. If needed, limit dose and duration to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation.

Risks of Medication Errors: Ensure accuracy when prescribing, dispensing, and administering oxycodone/acetaminophen oral solution; dosing errors due to confusion between mg and mL, and other oxycodone/acetaminophen oral solutions of different concentrations can result in accidental overdose and death.

Safety and efficacy have not been established in patients younger than 18 years.

US Controlled Substance: Schedule II

Dialysis: Data not available


Administration advice:

  • Take orally with or without food

Oral Solution:

  • Verify dose in mg and mL prior to administration
  • Measure dose with a calibrated measuring device

Extended-release tablets

  • Swallow whole, 1 tablet at a time with sufficient water to ensure complete swallowing
  • Do not break, chew, crush, cut, dissolve, or split tablets

Storage requirements:

  • Protect from light and moisture


  • The total acetaminophen dose should not exceed 4 g in 24 hours; be sure to account for all acetaminophen use when calculating total daily dose.
  • Because of the risks of addiction, abuse and misuse, the lowest dose for the shortest duration consistent with individual patient treatment goals should be used.
  • Frequent communication between members of the healthcare team, patients, and their caregiver/family is important during periods of changing analgesic requirements; if the level of pain increases after dose stabilization, an attempt should be made to identify the source of increased pain before increasing the dose of pain medication.
  • Oxycodone/acetaminophen formulations are not interchangeable because of differing pharmacokinetics; if patients switch from the immediate-release formulation to the extended-release tablet, monitor closely for signs of excessive sedation and respiratory depression.


  • Monitor for respiratory depression, especially during initiation and following any increase in dose; close monitoring will be necessary in patients at increased risk and/or those receiving concomitant medications that increase the risk of respiratory depression
  • Monitor for signs of hypotension
  • Monitor for signs of constipation
  • Monitor for the development of behaviors indicative of addiction, abuse, or misuse

What other drugs will affect Percocet?

Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use: other narcotic medications–opioid pain medicine or prescription cough medicine; a sedative like Valium–diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others); or drugs that make you sleepy or slow your breathing–a sleeping pill, muscle relaxer, tranquilizer, antidepressant, or antipsychotic medicine.

This list is not complete. Other drugs may interact with acetaminophen and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.



Since this medicine is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.



Seek emergency medical attention or call the Poison. An overdose can be fatal, especially in a child or other person using Percocet without a prescription. Overdose can cause severe muscle weakness, pinpoint pupils, very slow breathing, extreme drowsiness, or coma.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness.

What should I avoid while taking Percocet?

Do not drink alcohol. Dangerous side effects or death could occur.

This medicine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.



Applies to acetaminophen / oxycodone: oral capsule, oral solution, oral tablet, oral tablet extended release

Along with its needed effects, acetaminophen/oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / oxycodone:


More Common

  • Abdominal or stomach pain
  • black, tarry stools
  • chills
  • dark urine
  • dizziness
  • fever
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • nausea
  • rash
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin


  • Cough or hoarseness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • lower back or side pain
  • painful or difficult urination
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • unusual bleeding or bruising



Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.



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